Association of bisphenol A level with obesity

*Corresponding and presenting author:

Dr. Md. Sohel Rana Bhuiyan, Resident, Department of Endocrinology, BSMMU, Bangladesh. Cell: +88 01724455696, E-mail: m.s.rana34@gmail.com

ABSTRACT

Background: The prevalence of obesity has risen to unacceptable levels in both men and women worldwide with resultant hazardous health implications. Genetic, environmental, and behavioral factors influence the development of obesity. Recent evidence has shown a possible role of Bisphenol A (BPA), an environmental endocrine disruptor in the development of obesity.

Objectives: The aim was to see the level of BPA in patients with obesity (overweight and obese) in comparison to those with normal weight adults and to assess the association between BPA and obesity.

Methods: This cross-sectional study was conducted in the Department of Endocrinology, BSMMU from September 2020 to September 2022, enrolling 40 overweight and obese patients and equal number of normal weight subjects. Obesity was diagnosed based on WHO Expert Consultation 2004. After anthropometry, serum BPA was measured by ELISA method in all participants.

Results: The median age in overweight, obese group was 28 (23.25, 32.00) years and in normal group was 27.5 (23.00, 32.00) years. Mean BMI in overweight, obese group was 29.87(3.87) kg/m² and in normal weight group was 20.24(1.52) kg/m². There was no significant difference of serum BPA level between overweight, obese and normal weight group [0.60 (0.42, 1.23) vs. 0.97 (0.54, 1.54), ng/ml, median, p= 0.14]. Serum BPA did not correlate with BMI or any other indices of obesity in overweight and obese group (r = 0.02, R²=0.0004 p= 0.87) and in normal weight group (r = – 0.01, R²=0.0001, p= 0.91). BPA was not a predictor of generalized (OR= 0.18, 95% CI= 0.29 to 1.25, p= 0.18) or central obesity (OR= 0.73, 95% CI= 0.36 to 1.48, p= 0.39).

Conclusions: Serum BPA was not associated with obesity.

Keywords: Bisphenol A, overweight, obesity